Conformationally Selective RNA Aptamers Allosterically Modulate the β2-Adrenoceptor

Conformationally Selective RNA Aptamers Allosterically Modulate the β2-Adrenoceptor

G-protein-coupled receptor (GPCR) ligands function by stabilizing multiple, functionally distinct receptor conformations. This property underlies how “biased agonists” activate specific subsets of a given receptor’s signaling profile. However, stabilization of distinct active GPCR conformations to e...

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Bibliographic Details
Main Authors: Kahsai, Alem W., Wisler, James W., Lee, Jungmin, Ahn, Seungkirl, Cahill, Thomas J., Dennison, S. Moses, Staus, Dean P., Thomsen, Alex R. B., Anasti, Kara M., Pani, Biswaranjan, Wingler, Laura M., Desai, Hemant, Bompiani, Kristin M., Strachan, Ryan T., Qin, Xiaoxia, Alam, S. Munir, Sullenger, Bruce A., Lefkowitz, Robert J.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990464/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990464/

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