Molecular dynamics-based refinement and validation for sub-5 Å cryo-electron microscopy maps

Molecular dynamics-based refinement and validation for sub-5 Å cryo-electron microscopy maps

Two structure determination methods, based on the molecular dynamics flexible fitting (MDFF) paradigm, are presented that resolve sub-5 Å cryo-electron microscopy (EM) maps with either single structures or ensembles of such structures. The methods, denoted cascade MDFF and resolution exchange MDFF,...

Full description

Bibliographic Details
Main Authors: Singharoy, Abhishek, Teo, Ivan, McGreevy, Ryan, Stone, John E, Zhao, Jianhua, Schulten, Klaus
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990421/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990421/

Similar Items