Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge

Cancer is a leading cause of death worldwide. We aim to provide a systematic review about the roles of reactive oxygen species (ROS) in anticancer therapy with Salvia miltiorrhiza Bunge (Danshen). Danshen, including its lipophilic and hydrophilic constituents, is potentially beneficial for treating...

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Main Authors:	Hung, Yu-Chiang, Pan, Tai-Long, Hu, Wen-Long
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989081/

id	pubmed-4989081
recordtype	oai_dc
spelling	pubmed-49890812016-08-30 Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge Hung, Yu-Chiang Pan, Tai-Long Hu, Wen-Long Review Article Cancer is a leading cause of death worldwide. We aim to provide a systematic review about the roles of reactive oxygen species (ROS) in anticancer therapy with Salvia miltiorrhiza Bunge (Danshen). Danshen, including its lipophilic and hydrophilic constituents, is potentially beneficial for treating various cancers. The mechanisms of ROS-related anticancer effects of Danshen vary depending on the specific type of cancer cells involved. Danshen may enhance TNF-α-induced apoptosis, upregulate caspase-3, caspase-8, caspase-9, endoplasmic reticulum stress, P21, P53, Bax/Bcl-2, DR5, and AMP-activated protein kinase, or activate the p38/JNK, mitogen-activated protein kinase, and FasL signaling pathways. Conversely, Danshen may downregulate human telomerase reverse transcriptase mRNA, telomerase, survivin, vascular endothelial growth factor/vascular endothelial growth factor receptor 2, CD31, NF-κB, Erk1/2, matrix metalloproteinases, microtubule assembly, and receptor tyrosine kinases including epidermal growth factor receptors, HER2, and P-glycoprotein and inhibit the PI3K/Akt/mTOR or estrogen receptor signaling pathways. Therefore, Danshen may inhibit cancer cells proliferation through antioxidation on tumor initiation and induce apoptosis or autophagy through ROS generation on tumor progression, tumor promotion, and tumor metastasis. Based on the available evidence regarding its anticancer properties, this review provides new insights for further anticancer research or clinical trials with Danshen. Hindawi Publishing Corporation 2016 2016-08-04 /pmc/articles/PMC4989081/ /pubmed/27579153 http://dx.doi.org/10.1155/2016/5293284 Text en Copyright © 2016 Yu-Chiang Hung et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hung, Yu-Chiang Pan, Tai-Long Hu, Wen-Long
spellingShingle	Hung, Yu-Chiang Pan, Tai-Long Hu, Wen-Long Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge
author_facet	Hung, Yu-Chiang Pan, Tai-Long Hu, Wen-Long
author_sort	Hung, Yu-Chiang
title	Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge
title_short	Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge
title_full	Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge
title_fullStr	Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge
title_full_unstemmed	Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge
title_sort	roles of reactive oxygen species in anticancer therapy with salvia miltiorrhiza bunge
description	Cancer is a leading cause of death worldwide. We aim to provide a systematic review about the roles of reactive oxygen species (ROS) in anticancer therapy with Salvia miltiorrhiza Bunge (Danshen). Danshen, including its lipophilic and hydrophilic constituents, is potentially beneficial for treating various cancers. The mechanisms of ROS-related anticancer effects of Danshen vary depending on the specific type of cancer cells involved. Danshen may enhance TNF-α-induced apoptosis, upregulate caspase-3, caspase-8, caspase-9, endoplasmic reticulum stress, P21, P53, Bax/Bcl-2, DR5, and AMP-activated protein kinase, or activate the p38/JNK, mitogen-activated protein kinase, and FasL signaling pathways. Conversely, Danshen may downregulate human telomerase reverse transcriptase mRNA, telomerase, survivin, vascular endothelial growth factor/vascular endothelial growth factor receptor 2, CD31, NF-κB, Erk1/2, matrix metalloproteinases, microtubule assembly, and receptor tyrosine kinases including epidermal growth factor receptors, HER2, and P-glycoprotein and inhibit the PI3K/Akt/mTOR or estrogen receptor signaling pathways. Therefore, Danshen may inhibit cancer cells proliferation through antioxidation on tumor initiation and induce apoptosis or autophagy through ROS generation on tumor progression, tumor promotion, and tumor metastasis. Based on the available evidence regarding its anticancer properties, this review provides new insights for further anticancer research or clinical trials with Danshen.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989081/
_version_	1613629468621930496

Roles of Reactive Oxygen Species in Anticancer Therapy with Salvia miltiorrhiza Bunge

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