VPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras trafficking
Mutated N-Ras causes leukemia and melanoma when properly delivered to cellular membranes. Here, VPS35, a component of the retromer, is shown to carry N-Ras from one membrane compartment to another. Thus, VPS35 may be a target for anticancer drug discovery.
Bibliographic Details
| Main Authors: |
Zhou, Mo,
Wiener, Heidi,
Su, Wenjuan,
Zhou, Yong,
Liot, Caroline,
Ahearn, Ian,
Hancock, John F.,
Philips, Mark R. |
|---|
| Format: | Online
|
|---|
| Language: | English |
|---|
| Published: |
The Rockefeller University Press
2016
|
|---|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987297/
|
|---|