TMX1 determines cancer cell metabolism as a thiol-based modulator of ER–mitochondria Ca2+ flux

TMX1 determines cancer cell metabolism as a thiol-based modulator of ER–mitochondria Ca2+ flux

Cancer cells are critically dependent on ER–mitochondria Ca2+ flux that regulates their bioenergetics. Here, Raturi et al. identify the ER oxidoreductase TMX1 as a thiol-dependent regulator of this intracellular signaling mechanism within cancer cells.

Bibliographic Details
Main Authors: Raturi, Arun, Gutiérrez, Tomás, Ortiz-Sandoval, Carolina, Ruangkittisakul, Araya, Herrera-Cruz, Maria Sol, Rockley, Jeremy P., Gesson, Kevin, Ourdev, Dimitar, Lou, Phing-How, Lucchinetti, Eliana, Tahbaz, Nasser, Zaugg, Michael, Baksh, Shairaz, Ballanyi, Klaus, Simmen, Thomas
Format: Online
Language:English
Published: The Rockefeller University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987292/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987292/

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