Reversal of a Single Base‐Pair Step Controls Guanine Photo‐Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex†

Reversal of a Single Base‐Pair Step Controls Guanine Photo‐Oxidation by an Intercalating Ruthenium(II) Dipyridophenazine Complex†

Small changes in DNA sequence can often have major biological effects. Here the rates and yields of guanine photo‐oxidation by Λ‐[Ru(TAP)2(dppz)]2+ have been compared in 5′‐{CCGGATCCGG}2 and 5′‐{CCGGTACCGG}2 using pico/nanosecond transient visible and time‐resolved IR (TRIR) spectroscopy. The ineffi...

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Bibliographic Details
Main Authors: Keane, Páraic M., Poynton, Fergus E., Hall, James P., Sazanovich, Igor V., Towrie, Michael, Gunnlaugsson, Thorfinnur, Quinn, Susan J., Cardin, Christine J., Kelly, John M.
Format: Online
Language:English
Published: WILEY‐VCH Verlag 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985698/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985698/

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