Systems Analysis of the Dynamic Inflammatory Response to Tissue Damage Reveals Spatiotemporal Properties of the Wound Attractant Gradient

•Computational modeling of in vivo inflammatory response to tissue damage is applied•The model infers novel spatiotemporal properties of the wound attractant gradient•Wound signal is released from the wound edge for 30 min and diffuses at 200 μm2/min•Modeling two competing wounds reveals a period of...

Full description

Bibliographic Details
Main Authors: Weavers, Helen, Liepe, Juliane, Sim, Aaron, Wood, Will, Martin, Paul, Stumpf, Michael P.H.
Format: Online
Language:English
Published: Cell Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985561/