Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge

Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge

Current hemagglutinin (HA)-based seasonal influenza vaccines induce vaccine strain-specific neutralizing antibodies that usually fail to provide protection against mismatched circulating viruses. Inclusion in the vaccine of highly conserved internal proteins such as the nucleoprotein (NP) and the ma...

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Bibliographic Details
Main Authors: Magini, Diletta, Giovani, Cinzia, Mangiavacchi, Simona, Maccari, Silvia, Cecchi, Raffaella, Ulmer, Jeffrey B., De Gregorio, Ennio, Geall, Andrew J., Brazzoli, Michela, Bertholet, Sylvie
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985159/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985159/

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