p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies

p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies

Mallory-Denk bodies (MDBs) are hepatocytic protein aggregates found in steatohepatitis and several other chronic liver diseases as well as hepatocellular carcinoma. MDBs are mainly composed of phosphorylated keratins and stress protein p62/Sequestosome-1 (p62), which is a common component of cytopla...

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Bibliographic Details
Main Authors:	Lahiri, Pooja, Schmidt, Volker, Smole, Claudia, Kufferath, Iris, Denk, Helmut, Strnad, Pavel, Rülicke, Thomas, Fröhlich, Leopold F., Zatloukal, Kurt
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985067/

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