Alcohol and Aldehyde Dehydrogenases Contribute to Sex-Related Differences in Clearance of Zolpidem in Rats

Alcohol and Aldehyde Dehydrogenases Contribute to Sex-Related Differences in Clearance of Zolpidem in Rats

Objectives: The recommended zolpidem starting dose was lowered in females (5 mg vs. 10 mg) since side effects were more frequent and severe than those of males; the mechanism underlying sex differences in pharmacokinetics (PK) is unknown. We hypothesized that such differences were caused by known se...

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Bibliographic Details
Main Authors: Peer, Cody J., Strope, Jonathan D., Beedie, Shaunna, Ley, Ariel M., Holly, Alesia, Calis, Karim, Farkas, Ronald, Parepally, Jagan, Men, Angela, Fadiran, Emmanuel O., Scott, Pamela, Jenkins, Marjorie, Theodore, William H., Sissung, Tristan M.
Format: Online
Language:English
Published: Frontiers Media S.A. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983555/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983555/

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