7SK-BAF axis controls pervasive transcription at enhancers

7SK-BAF axis controls pervasive transcription at enhancers

RNA functions at enhancers remain mysterious. Here we show that the 7SK small nuclear RNA (snRNA) inhibits enhancer transcription by modulating nucleosome position. 7SK occupies enhancers and super enhancers genome-wide in mouse and human cells, and 7SK is required to limit eRNA initiation and synth...

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Bibliographic Details
Main Authors: Flynn, Ryan A., Do, Brian T., Rubin, Adam J., Calo, Eliezer, Lee, Byron, Kuchelmeister, Hannes, Rale, Michael, Chu, Ci, Kool, Eric T., Wysocka, Joanna, Khavari, Paul A., Chang, Howard Y.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982704/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982704/

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