Modulation of Alloimmunity by Heat Shock Proteins
The immunological mechanisms that evolved for host defense against pathogens and injury are also responsible for transplant rejection. Host rejection of foreign tissue was originally thought to be mediated mainly by T cell recognition of foreign MHC alleles. Management of solid organ transplant reje...
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Frontiers Media S.A.
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977877/ |
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pubmed-49778772016-08-23 Modulation of Alloimmunity by Heat Shock Proteins Borges, Thiago J. Lang, Benjamin J. Lopes, Rafael L. Bonorino, Cristina Immunology The immunological mechanisms that evolved for host defense against pathogens and injury are also responsible for transplant rejection. Host rejection of foreign tissue was originally thought to be mediated mainly by T cell recognition of foreign MHC alleles. Management of solid organ transplant rejection has thus focused mainly on inhibition of T cell function and matching MHC alleles between donor and host. Recently, however, it has been demonstrated that the magnitude of the initial innate immune responses upon transplantation has a decisive impact on rejection. The exact mechanisms underlying this phenomenon have yet to be characterized. Ischemic cell death and inflammation that occur upon transplantation are synonymous with extracellular release of various heat shock proteins (Hsps), many of which have been shown to have immune-modulatory properties. Here, we review the impact of Hsps upon alloimmunity and discuss the potential use of Hsps as accessory agents to improve solid organ transplant outcomes. Frontiers Media S.A. 2016-08-09 /pmc/articles/PMC4977877/ /pubmed/27555846 http://dx.doi.org/10.3389/fimmu.2016.00303 Text en Copyright © 2016 Borges, Lang, Lopes and Bonorino. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Borges, Thiago J. Lang, Benjamin J. Lopes, Rafael L. Bonorino, Cristina |
| spellingShingle |
Borges, Thiago J. Lang, Benjamin J. Lopes, Rafael L. Bonorino, Cristina Modulation of Alloimmunity by Heat Shock Proteins |
| author_facet |
Borges, Thiago J. Lang, Benjamin J. Lopes, Rafael L. Bonorino, Cristina |
| author_sort |
Borges, Thiago J. |
| title |
Modulation of Alloimmunity by Heat Shock Proteins |
| title_short |
Modulation of Alloimmunity by Heat Shock Proteins |
| title_full |
Modulation of Alloimmunity by Heat Shock Proteins |
| title_fullStr |
Modulation of Alloimmunity by Heat Shock Proteins |
| title_full_unstemmed |
Modulation of Alloimmunity by Heat Shock Proteins |
| title_sort |
modulation of alloimmunity by heat shock proteins |
| description |
The immunological mechanisms that evolved for host defense against pathogens and injury are also responsible for transplant rejection. Host rejection of foreign tissue was originally thought to be mediated mainly by T cell recognition of foreign MHC alleles. Management of solid organ transplant rejection has thus focused mainly on inhibition of T cell function and matching MHC alleles between donor and host. Recently, however, it has been demonstrated that the magnitude of the initial innate immune responses upon transplantation has a decisive impact on rejection. The exact mechanisms underlying this phenomenon have yet to be characterized. Ischemic cell death and inflammation that occur upon transplantation are synonymous with extracellular release of various heat shock proteins (Hsps), many of which have been shown to have immune-modulatory properties. Here, we review the impact of Hsps upon alloimmunity and discuss the potential use of Hsps as accessory agents to improve solid organ transplant outcomes. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977877/ |
| _version_ |
1613624034663071744 |