Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-Antibodies

Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-Antibodies

Mechanisms leading to decreased platelet count in immune thrombocytopenia (ITP) are heterogeneous. This study describes increased platelet apoptosis involving loss of mitochondrial membrane potential (ΔΨm), caspase 3 activation (aCasp3) and phosphatidylserine (PS) externalization in a cohort of adul...

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Bibliographic Details
Main Authors: Goette, Nora P., Glembotsky, Ana C., Lev, Paola R., Grodzielski, Matías, Contrufo, Geraldine, Pierdominici, Marta S., Espasandin, Yesica R., Riveros, Dardo, García, Alejandro J., Molinas, Felisa C., Heller, Paula G., Marta, Rosana F.
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975454/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975454/

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