Procalcitonin and Other Biomarkers of Sepsis in Newborns in the Intensive Care Unit

Neonatal sepsis is one of the most significant causes of mortality and morbidity in infants. Among numerous parameters available to confirm the presence of sepsis in newborns procalcitonin (PCT) has been chosen. The aim of this study was the determination of PCT, C-reactive protein (CRP) serum amylo...

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Main Authors:	Bartolovic, Daniela, Ignjatovic, Svetlana, Stankovic, Sanja, Nada Majkić, Singh
Format:	Online
Language:	English
Published:	The Communications and Publications Division (CPD) of the IFCC 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975328/

id	pubmed-4975328
recordtype	oai_dc
spelling	pubmed-49753282016-09-28 Procalcitonin and Other Biomarkers of Sepsis in Newborns in the Intensive Care Unit Bartolovic, Daniela Ignjatovic, Svetlana Stankovic, Sanja Nada Majkić, Singh Research Article Neonatal sepsis is one of the most significant causes of mortality and morbidity in infants. Among numerous parameters available to confirm the presence of sepsis in newborns procalcitonin (PCT) has been chosen. The aim of this study was the determination of PCT, C-reactive protein (CRP) serum amyloid A (SAA), plasminogen, protein C, antithrombin III (AT III) and white blood cell count (WBC) in blood sample obtained by puncture of the umbilical vein. Sixty two newborn infants were included in the study: 31 with suspected bacterial infection and 31 healthy babies Serum procalcitonin was measured using Kryptor analyzer (Brahms Aktiengesellschaft, Germany); serum hsCRP and SAA on the Behring Nephelometer II (Dade Behring Diagnostics GmbH, Marburg, Germany); plasma plasminogen, protein C and AT III on BCT Coagulation system, (Dade Behring Diagnostics GmbH, Marburg, Germany); and WBC count was determined in the whole blood using hematological analyzer ADVIA 120 Hematology System (Bayer, Germany). The obtained mean values of PCT, hsCRP, SAA, WBC, plasminogen, AT III, protein C in newborn’s samples with suspected bacterial infection/healthy newborns were: 0.188 ng/L / 0.121 ng/L; 1.20 mg/L / 1.30 mg/L, 1.28% / 1.70%; 16.0 x 109/L/12.0 x 109 / L, 61.0% / 59.0%, 52.0% / 64.5%, 39.0% / 41.0%, respectively. Neonates with bacterial infection had significantly higher values of PCT (p <0.001), WBC (p <0.001) and CRP (p <0.05) compared to healthy babies. Based on these results, it may be concluded that procalcitonin is useful for early diagnosis of sepsis in newborns. The Communications and Publications Division (CPD) of the IFCC 2011-03-14 /pmc/articles/PMC4975328/ /pubmed/27683386 Text en Copyright © 2011 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bartolovic, Daniela Ignjatovic, Svetlana Stankovic, Sanja Nada Majkić, Singh
spellingShingle	Bartolovic, Daniela Ignjatovic, Svetlana Stankovic, Sanja Nada Majkić, Singh Procalcitonin and Other Biomarkers of Sepsis in Newborns in the Intensive Care Unit
author_facet	Bartolovic, Daniela Ignjatovic, Svetlana Stankovic, Sanja Nada Majkić, Singh
author_sort	Bartolovic, Daniela
title	Procalcitonin and Other Biomarkers of Sepsis in Newborns in the Intensive Care Unit
title_short	Procalcitonin and Other Biomarkers of Sepsis in Newborns in the Intensive Care Unit
title_full	Procalcitonin and Other Biomarkers of Sepsis in Newborns in the Intensive Care Unit
title_fullStr	Procalcitonin and Other Biomarkers of Sepsis in Newborns in the Intensive Care Unit
title_full_unstemmed	Procalcitonin and Other Biomarkers of Sepsis in Newborns in the Intensive Care Unit
title_sort	procalcitonin and other biomarkers of sepsis in newborns in the intensive care unit
description	Neonatal sepsis is one of the most significant causes of mortality and morbidity in infants. Among numerous parameters available to confirm the presence of sepsis in newborns procalcitonin (PCT) has been chosen. The aim of this study was the determination of PCT, C-reactive protein (CRP) serum amyloid A (SAA), plasminogen, protein C, antithrombin III (AT III) and white blood cell count (WBC) in blood sample obtained by puncture of the umbilical vein. Sixty two newborn infants were included in the study: 31 with suspected bacterial infection and 31 healthy babies Serum procalcitonin was measured using Kryptor analyzer (Brahms Aktiengesellschaft, Germany); serum hsCRP and SAA on the Behring Nephelometer II (Dade Behring Diagnostics GmbH, Marburg, Germany); plasma plasminogen, protein C and AT III on BCT Coagulation system, (Dade Behring Diagnostics GmbH, Marburg, Germany); and WBC count was determined in the whole blood using hematological analyzer ADVIA 120 Hematology System (Bayer, Germany). The obtained mean values of PCT, hsCRP, SAA, WBC, plasminogen, AT III, protein C in newborn’s samples with suspected bacterial infection/healthy newborns were: 0.188 ng/L / 0.121 ng/L; 1.20 mg/L / 1.30 mg/L, 1.28% / 1.70%; 16.0 x 109/L/12.0 x 109 / L, 61.0% / 59.0%, 52.0% / 64.5%, 39.0% / 41.0%, respectively. Neonates with bacterial infection had significantly higher values of PCT (p <0.001), WBC (p <0.001) and CRP (p <0.05) compared to healthy babies. Based on these results, it may be concluded that procalcitonin is useful for early diagnosis of sepsis in newborns.
publisher	The Communications and Publications Division (CPD) of the IFCC
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975328/
_version_	1613622476333383680

Procalcitonin and Other Biomarkers of Sepsis in Newborns in the Intensive Care Unit

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