Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke

The possible association of ACE polymorphism with ischemic stroke (IS) was evaluated in 65 patients with IS and 330 age and BMI-matched controls. ACE genotypes were determined by polymerase chain reaction (PCR). There was no significant difference in ACE genotype/allele frequencies between case and...

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Main Authors:	Stankovic, Sanja, Stankovic, Aleksandra, Asanin, Milika, Jovanovic-Markovic, Zagorka, Alavantic, Dragan, Majkic-Singh, Nada
Format:	Online
Language:	English
Published:	The Communications and Publications Division (CPD) of the IFCC 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975320/

id	pubmed-4975320
recordtype	oai_dc
spelling	pubmed-49753202016-09-28 Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke Stankovic, Sanja Stankovic, Aleksandra Asanin, Milika Jovanovic-Markovic, Zagorka Alavantic, Dragan Majkic-Singh, Nada Research Article The possible association of ACE polymorphism with ischemic stroke (IS) was evaluated in 65 patients with IS and 330 age and BMI-matched controls. ACE genotypes were determined by polymerase chain reaction (PCR). There was no significant difference in ACE genotype/allele frequencies between case and control group (p>0.05). Patients with D allele had 4,7 times higher risk for large vessel IS than healthy persons D allele possessors. Persons with D allele had 9.2 times higher risk for large vessel disease than small vessel disease. These data suggest a possible association of ACE gene polymorphism with pathogenesis of large vessel IS. The Communications and Publications Division (CPD) of the IFCC 2011-01-03 /pmc/articles/PMC4975320/ /pubmed/27683381 Text en Copyright © 2010 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Stankovic, Sanja Stankovic, Aleksandra Asanin, Milika Jovanovic-Markovic, Zagorka Alavantic, Dragan Majkic-Singh, Nada
spellingShingle	Stankovic, Sanja Stankovic, Aleksandra Asanin, Milika Jovanovic-Markovic, Zagorka Alavantic, Dragan Majkic-Singh, Nada Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
author_facet	Stankovic, Sanja Stankovic, Aleksandra Asanin, Milika Jovanovic-Markovic, Zagorka Alavantic, Dragan Majkic-Singh, Nada
author_sort	Stankovic, Sanja
title	Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title_short	Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title_full	Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title_fullStr	Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title_full_unstemmed	Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke
title_sort	angiotensin i - converting enzyme gene polymorphism and activity in patients with ischemic stroke
description	The possible association of ACE polymorphism with ischemic stroke (IS) was evaluated in 65 patients with IS and 330 age and BMI-matched controls. ACE genotypes were determined by polymerase chain reaction (PCR). There was no significant difference in ACE genotype/allele frequencies between case and control group (p>0.05). Patients with D allele had 4,7 times higher risk for large vessel IS than healthy persons D allele possessors. Persons with D allele had 9.2 times higher risk for large vessel disease than small vessel disease. These data suggest a possible association of ACE gene polymorphism with pathogenesis of large vessel IS.
publisher	The Communications and Publications Division (CPD) of the IFCC
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975320/
_version_	1613622467961552896

Angiotensin I - Converting Enzyme Gene Polymorphism and Activity in Patients with Ischemic Stroke

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