Gametocytogenesis : the puberty of Plasmodium falciparum
The protozoan Plasmodium falciparum has a complex life cycle in which asexual multiplication in the vertebrate host alternates with an obligate sexual reproduction in the anopheline mosquito. Apart from the apparent recombination advantages conferred by sex, P. falciparum has evolved a remarkable bi...
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| Format: | Online |
| Language: | English |
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BioMed Central
2004
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC497046/ |
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pubmed-4970462004-07-31 Gametocytogenesis : the puberty of Plasmodium falciparum Talman, Arthur M Domarle, Olivier McKenzie, F Ellis Ariey, Frédéric Robert, Vincent Review The protozoan Plasmodium falciparum has a complex life cycle in which asexual multiplication in the vertebrate host alternates with an obligate sexual reproduction in the anopheline mosquito. Apart from the apparent recombination advantages conferred by sex, P. falciparum has evolved a remarkable biology and adaptive phenotypes to insure its transmission despite the dangers of sex. This review mainly focuses on the current knowledge on commitment to sexual development, gametocytogenesis and the evolutionary significance of various aspects of gametocyte biology. It goes further than pure biology to look at the strategies used to improve successful transmission. Although gametocytes are inevitable stages for transmission and provide a potential target to fight malaria, they have received less attention than the pathogenic asexual stages. There is a need for research on gametocytes, which are a fascinating stage, responsible to a large extent for the success of P. falciparum. BioMed Central 2004-07-14 /pmc/articles/PMC497046/ /pubmed/15253774 http://dx.doi.org/10.1186/1475-2875-3-24 Text en Copyright © 2004 Talman et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Talman, Arthur M Domarle, Olivier McKenzie, F Ellis Ariey, Frédéric Robert, Vincent |
| spellingShingle |
Talman, Arthur M Domarle, Olivier McKenzie, F Ellis Ariey, Frédéric Robert, Vincent Gametocytogenesis : the puberty of Plasmodium falciparum |
| author_facet |
Talman, Arthur M Domarle, Olivier McKenzie, F Ellis Ariey, Frédéric Robert, Vincent |
| author_sort |
Talman, Arthur M |
| title |
Gametocytogenesis : the puberty of Plasmodium falciparum |
| title_short |
Gametocytogenesis : the puberty of Plasmodium falciparum |
| title_full |
Gametocytogenesis : the puberty of Plasmodium falciparum |
| title_fullStr |
Gametocytogenesis : the puberty of Plasmodium falciparum |
| title_full_unstemmed |
Gametocytogenesis : the puberty of Plasmodium falciparum |
| title_sort |
gametocytogenesis : the puberty of plasmodium falciparum |
| description |
The protozoan Plasmodium falciparum has a complex life cycle in which asexual multiplication in the vertebrate host alternates with an obligate sexual reproduction in the anopheline mosquito. Apart from the apparent recombination advantages conferred by sex, P. falciparum has evolved a remarkable biology and adaptive phenotypes to insure its transmission despite the dangers of sex. This review mainly focuses on the current knowledge on commitment to sexual development, gametocytogenesis and the evolutionary significance of various aspects of gametocyte biology. It goes further than pure biology to look at the strategies used to improve successful transmission. Although gametocytes are inevitable stages for transmission and provide a potential target to fight malaria, they have received less attention than the pathogenic asexual stages. There is a need for research on gametocytes, which are a fascinating stage, responsible to a large extent for the success of P. falciparum. |
| publisher |
BioMed Central |
| publishDate |
2004 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC497046/ |
| _version_ |
1611369157353275392 |