Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions

Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions

Stromal cells and osteoblasts play major roles in forming and modulating the bone marrow (BM) hematopoietic microenvironment. We have reported that FGF2 compromises stromal cell support of normal hematopoiesis. Here, we examined the effects of FGF2 on the leukemia microenvironment. In vitro, FGF2 si...

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Bibliographic Details
Main Authors: Sugimoto, Keiki, Miyata, Yasuhiko, Nakayama, Takayuki, Saito, Shigeki, Suzuki, Ritsuro, Hayakawa, Fumihiko, Nishiwaki, Satoshi, Mizuno, Hiroki, Takeshita, Kyosuke, Kato, Hidefumi, Ueda, Ryuzo, Takami, Akiyoshi, Naoe, Tomoki
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969776/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969776/

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