Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness

Objective. Osteoarthritis (OA) is associated with increased cardiovascular comorbidity and mortality. Evidence is lacking about whether arterial stiffness is involved in OA. The objective of our study was to find out associations between OA, arterial stiffness, and adipokines. Design. Seventy end-s...

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Main Authors:	Tootsi, Kaspar, Kals, Jaak, Zilmer, Mihkel, Paapstel, Kaido, Märtson, Aare
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967435/

id	pubmed-4967435
recordtype	oai_dc
spelling	pubmed-49674352016-08-04 Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness Tootsi, Kaspar Kals, Jaak Zilmer, Mihkel Paapstel, Kaido Märtson, Aare Research Article Objective. Osteoarthritis (OA) is associated with increased cardiovascular comorbidity and mortality. Evidence is lacking about whether arterial stiffness is involved in OA. The objective of our study was to find out associations between OA, arterial stiffness, and adipokines. Design. Seventy end-stage knee and hip OA patients (age 62 ± 7 years) and 70 asymptomatic controls (age 60 ± 7 years) were investigated using the applanation tonometry to determine their parameters of arterial stiffness. Serum adiponectin, leptin, and matrix metalloproteinase 3 (MMP-3) levels were determined using the ELISA method. Correlation between variables was determined using Spearman's rho. Multiple regression analysis with a stepwise selection procedure was employed. Results. Radiographic OA grade was positively associated with increased carotid-femoral pulse wave velocity (cf-PWV) (r = 0.272, p = 0.023). We found that OA grade was also associated with leptin and MMP-3 levels (rho = −0.246, p = 0.040 and rho = 0.235, p = 0.050, resp.). In addition, serum adiponectin level was positively associated with augmentation index and inversely with large artery elasticity index (rho = 0.293, p = 0.006 and rho = −0.249, p = 0.003, resp.). Conclusions. Our results suggest that OA severity is independently associated with increased arterial stiffness and is correlated with expression of adipokines. Thus, increased arterial stiffness and adipokines might play an important role in elevated cardiovascular risk in end-stage OA. Hindawi Publishing Corporation 2016 2016-07-17 /pmc/articles/PMC4967435/ /pubmed/27493667 http://dx.doi.org/10.1155/2016/6402963 Text en Copyright © 2016 Kaspar Tootsi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tootsi, Kaspar Kals, Jaak Zilmer, Mihkel Paapstel, Kaido Märtson, Aare
spellingShingle	Tootsi, Kaspar Kals, Jaak Zilmer, Mihkel Paapstel, Kaido Märtson, Aare Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness
author_facet	Tootsi, Kaspar Kals, Jaak Zilmer, Mihkel Paapstel, Kaido Märtson, Aare
author_sort	Tootsi, Kaspar
title	Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness
title_short	Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness
title_full	Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness
title_fullStr	Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness
title_full_unstemmed	Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness
title_sort	severity of osteoarthritis is associated with increased arterial stiffness
description	Objective. Osteoarthritis (OA) is associated with increased cardiovascular comorbidity and mortality. Evidence is lacking about whether arterial stiffness is involved in OA. The objective of our study was to find out associations between OA, arterial stiffness, and adipokines. Design. Seventy end-stage knee and hip OA patients (age 62 ± 7 years) and 70 asymptomatic controls (age 60 ± 7 years) were investigated using the applanation tonometry to determine their parameters of arterial stiffness. Serum adiponectin, leptin, and matrix metalloproteinase 3 (MMP-3) levels were determined using the ELISA method. Correlation between variables was determined using Spearman's rho. Multiple regression analysis with a stepwise selection procedure was employed. Results. Radiographic OA grade was positively associated with increased carotid-femoral pulse wave velocity (cf-PWV) (r = 0.272, p = 0.023). We found that OA grade was also associated with leptin and MMP-3 levels (rho = −0.246, p = 0.040 and rho = 0.235, p = 0.050, resp.). In addition, serum adiponectin level was positively associated with augmentation index and inversely with large artery elasticity index (rho = 0.293, p = 0.006 and rho = −0.249, p = 0.003, resp.). Conclusions. Our results suggest that OA severity is independently associated with increased arterial stiffness and is correlated with expression of adipokines. Thus, increased arterial stiffness and adipokines might play an important role in elevated cardiovascular risk in end-stage OA.
publisher	Hindawi Publishing Corporation
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967435/
_version_	1613618203779399680

Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness

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