Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial–mesenchymal transition

Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial–mesenchymal transition

GRHL2 suppresses EMT to give a default epithelial phenotype. GRHL2 inhibits this process through the histone acetyltransferase coactivator p300, repressing the partial EMT and preventing induction of MMPs. The results demonstrate novel roles for p300 and GRHL2 in promoting or suppressing EMT in morp...

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Bibliographic Details
Main Authors: Pifer, Phillip M., Farris, Joshua C., Thomas, Alyssa L., Stoilov, Peter, Denvir, James, Smith, David M., Frisch, Steven M.
Format: Online
Language:English
Published: The American Society for Cell Biology 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966987/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966987/

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