Co‐recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR‐induced ubiquitylation

Co‐recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR‐induced ubiquitylation

T‐cell receptor (TCR) signaling is essential for the function of T cells and negatively regulated by the E3 ubiquitin–protein ligases CBL and CBLB. Here, we combined mouse genetics and affinity purification coupled to quantitative mass spectrometry to monitor the dynamics of the CBL and CBLB signali...

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Bibliographic Details
Main Authors: Voisinne, Guillaume, García‐Blesa, Antonio, Chaoui, Karima, Fiore, Frédéric, Bergot, Elise, Girard, Laura, Malissen, Marie, Burlet‐Schiltz, Odile, Gonzalez de Peredo, Anne, Malissen, Bernard, Roncagalli, Romain
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965873/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965873/

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