CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection

Mycobacterium tuberculosis (Mtb), possesses at least three type VII secretion systems, ESX-1, -3 and -5 that are actively involved in pathogenesis and host-pathogen interaction. We recently showed that an attenuated Mtb vaccine candidate (Mtb Δppe25-pe19), which lacks the characteristic ESX-5-assoc...

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Bibliographic Details
Main Authors: Sayes, Fadel, Pawlik, Alexandre, Frigui, Wafa, Gröschel, Matthias I., Crommelynck, Samuel, Fayolle, Catherine, Cia, Felipe, Bancroft, Gregory J., Bottai, Daria, Leclerc, Claude, Brosch, Roland, Majlessi, Laleh
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965174/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965174/

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