Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa

Here we propose a mechanism of cell targeting and translocation for an S-type pyocin, pyocin SD2. Understanding and exploiting the mechanisms by which pyocins target, penetrate and kill Pseudomonas aeruginosa is a promising approach to antibiotic development.

Bibliographic Details
Main Authors: McCaughey, Laura C., Josts, Inokentijs, Grinter, Rhys, White, Paul, Byron, Olwyn, Tucker, Nicholas P., Matthews, Jacqueline M., Kleanthous, Colin, Whitchurch, Cynthia B., Walker, Daniel
Format: Online
Language:English
Published: Portland Press Ltd. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964976/