Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear accumulation. The MRTFs also undergo Rho- and ERK-d...

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Bibliographic Details
Main Authors: Panayiotou, Richard, Miralles, Francesc, Pawlowski, Rafal, Diring, Jessica, Flynn, Helen R, Skehel, Mark, Treisman, Richard
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963197/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963197/

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