SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary

Sox2 mutations are associated with pituitary hormone deficiencies and the protein is required for pituitary progenitor proliferation, but its function has not been well characterized in this context. SOX2 is known to activate expression of Six6, encoding a homeodomain transcription factor, in the ve...

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Bibliographic Details
Main Authors: Goldsmith, Sam, Lovell-Badge, Robin, Rizzoti, Karine
Format: Online
Language:English
Published: The Company of Biologists Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958329/