Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment

Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment

During T cell development, multipotent progenitors relinquish competence for other fates and commit to the T cell lineage by turning on the transcription factor Bcl11b. To clarify lineage commitment mechanisms, we followed developing T cells at single-cell level using Bcl11b knock-in fluorescent rep...

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Bibliographic Details
Main Authors: Kueh, Hao Yuan, Yui, Mary A., Ng, Kenneth K.H., Pease, Shirley S., Zhang, Jingli A., Damle, Sagar S., Freedman, George, Siu, Sharmayne, Bernstein, Irwin D., Elowitz, Michael B., Rothenberg, Ellen V.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955789/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955789/

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