Hypoxia-mediated impaired erythrocyte Lands’ Cycle is pathogenic for sickle cell disease

Although Lands’ cycle was discovered in 1958, its function and cellular regulation in membrane homeostasis under physiological and pathological conditions remain largely unknown. Nonbiased high throughput metabolomic profiling revealed that Lands’ cycle was impaired leading to significantly elevated...

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Bibliographic Details
Main Authors: Wu, Hongyu, Bogdanov, Mikhail, Zhang, Yujin, Sun, Kaiqi, Zhao, Shushan, Song, Anren, Luo, Renna, Parchim, Nicholas F., Liu, Hong, Huang, Aji, Adebiyi, Morayo G., Jin, Jianping, Alexander, Danny C., Milburn, Michael V., Idowu, Modupe, Juneja, Harinder S., Kellems, Rodney E., Dowhan, William, Xia, Yang
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951653/