Zika virus challenges for neuropsychiatry

Zika virus challenges for neuropsychiatry

Before 2007, Zika virus (ZIKV) was generally considered as an arbovirus of low clinical relevance, causing a mild self-limiting febrile illness in tropical Africa and Southeast Asia. Currently, a large, ongoing outbreak of ZIKV that started in Brazil in 2015 is spreading across the Americas. Virus i...

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Main Authors: Simões e Silva, Ana Cristina, Moreira, Janaina Matos, Romanelli, Roberta Maia Castro, Teixeira, Antonio Lucio
Format: Online
Language:English
Published: Dove Medical Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951060/
id pubmed-4951060
recordtype oai_dc
spelling pubmed-49510602016-07-29 Zika virus challenges for neuropsychiatry Simões e Silva, Ana Cristina Moreira, Janaina Matos Romanelli, Roberta Maia Castro Teixeira, Antonio Lucio Review Before 2007, Zika virus (ZIKV) was generally considered as an arbovirus of low clinical relevance, causing a mild self-limiting febrile illness in tropical Africa and Southeast Asia. Currently, a large, ongoing outbreak of ZIKV that started in Brazil in 2015 is spreading across the Americas. Virus infection during pregnancy has been potentially linked to congenital malformations, including microcephaly. In addition to congenital malformations, a temporal association between ZIKV infection and an increase in cases of Guillain–Barré syndrome is currently being observed in several countries. The mechanisms underlying these neurological complications are still unknown. Emerging evidence, mainly from in vitro studies, suggests that ZIKV may have direct effects on neuronal cells. The aim of this study was to critically review the literature available regarding the neurobiology of ZIKV and its potential neuropsychiatric manifestations. Dove Medical Press 2016-07-14 /pmc/articles/PMC4951060/ /pubmed/27478378 http://dx.doi.org/10.2147/NDT.S113037 Text en © 2016 Simões e Silva et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Simões e Silva, Ana Cristina
Moreira, Janaina Matos
Romanelli, Roberta Maia Castro
Teixeira, Antonio Lucio
spellingShingle Simões e Silva, Ana Cristina
Moreira, Janaina Matos
Romanelli, Roberta Maia Castro
Teixeira, Antonio Lucio
Zika virus challenges for neuropsychiatry
author_facet Simões e Silva, Ana Cristina
Moreira, Janaina Matos
Romanelli, Roberta Maia Castro
Teixeira, Antonio Lucio
author_sort Simões e Silva, Ana Cristina
title Zika virus challenges for neuropsychiatry
title_short Zika virus challenges for neuropsychiatry
title_full Zika virus challenges for neuropsychiatry
title_fullStr Zika virus challenges for neuropsychiatry
title_full_unstemmed Zika virus challenges for neuropsychiatry
title_sort zika virus challenges for neuropsychiatry
description Before 2007, Zika virus (ZIKV) was generally considered as an arbovirus of low clinical relevance, causing a mild self-limiting febrile illness in tropical Africa and Southeast Asia. Currently, a large, ongoing outbreak of ZIKV that started in Brazil in 2015 is spreading across the Americas. Virus infection during pregnancy has been potentially linked to congenital malformations, including microcephaly. In addition to congenital malformations, a temporal association between ZIKV infection and an increase in cases of Guillain–Barré syndrome is currently being observed in several countries. The mechanisms underlying these neurological complications are still unknown. Emerging evidence, mainly from in vitro studies, suggests that ZIKV may have direct effects on neuronal cells. The aim of this study was to critically review the literature available regarding the neurobiology of ZIKV and its potential neuropsychiatric manifestations.
publisher Dove Medical Press
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951060/
_version_ 1613611858793594880

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