Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy
The aim of the study was to compare the clinical effects of carvedilol and trimetazidine for the treatment of alcoholic cardiomyopathy. A total of 60 patients diagnosed with alcoholic cardiomyopathy were enrolled in the study. The patients were randomly divided into the carvedilol (n=20), trimetazid...
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D.A. Spandidos
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950288/ |
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pubmed-49502882016-07-21 Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy Li, Hui Liu, Fu-Yuan Li, Xiao-Lan Li, Xiao-Mei Zhu, Lei Articles The aim of the study was to compare the clinical effects of carvedilol and trimetazidine for the treatment of alcoholic cardiomyopathy. A total of 60 patients diagnosed with alcoholic cardiomyopathy were enrolled in the study. The patients were randomly divided into the carvedilol (n=20), trimetazidine (n=20) and control (n=20) groups. The patients in the control, carvedilol and trimetazidine groups were treated with conventional drugs, conventional drugs + carvedil and conventional drugs + trimetazidine respectively, for 12 weeks. The patients were compared for their heart functions [left ventricular ejection fraction (LVEF), C-reactive protein (CRP) and 6 min walking], heart rate, blood pressure and heart enlargement (cardiothoracic proportion and left ventricular diameter) before and after treatment. The parameters studied for heart functions, heart rate, blood pressure, heart enlargement, clinical effects before and after treatment were statistically insignificant (p>0.05). After treatment, the carvedilol and trimetazidine groups showed higher LVEF and CRP, longer walking distance in 6 min, as well as lower heart rate and blood pressure (both systolic and diastolic) compared to the control group. Similarly, the cardiothoracic proportion and left ventricular internal diameter for the carvedilol and trimetazidine groups was lower than those of the control group, with better clinical effects (p<0.05). In conclusion, the curative effects of the carvedilol and trimetazidine groups of alcoholic myocardiopathy similar. Both are safe agents that may improve the cardiac function and heart expansion of patients. D.A. Spandidos 2016-08 2016-05-19 /pmc/articles/PMC4950288/ /pubmed/27446307 http://dx.doi.org/10.3892/etm.2016.3363 Text en Copyright: © Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Li, Hui Liu, Fu-Yuan Li, Xiao-Lan Li, Xiao-Mei Zhu, Lei |
| spellingShingle |
Li, Hui Liu, Fu-Yuan Li, Xiao-Lan Li, Xiao-Mei Zhu, Lei Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy |
| author_facet |
Li, Hui Liu, Fu-Yuan Li, Xiao-Lan Li, Xiao-Mei Zhu, Lei |
| author_sort |
Li, Hui |
| title |
Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy |
| title_short |
Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy |
| title_full |
Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy |
| title_fullStr |
Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy |
| title_full_unstemmed |
Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy |
| title_sort |
clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy |
| description |
The aim of the study was to compare the clinical effects of carvedilol and trimetazidine for the treatment of alcoholic cardiomyopathy. A total of 60 patients diagnosed with alcoholic cardiomyopathy were enrolled in the study. The patients were randomly divided into the carvedilol (n=20), trimetazidine (n=20) and control (n=20) groups. The patients in the control, carvedilol and trimetazidine groups were treated with conventional drugs, conventional drugs + carvedil and conventional drugs + trimetazidine respectively, for 12 weeks. The patients were compared for their heart functions [left ventricular ejection fraction (LVEF), C-reactive protein (CRP) and 6 min walking], heart rate, blood pressure and heart enlargement (cardiothoracic proportion and left ventricular diameter) before and after treatment. The parameters studied for heart functions, heart rate, blood pressure, heart enlargement, clinical effects before and after treatment were statistically insignificant (p>0.05). After treatment, the carvedilol and trimetazidine groups showed higher LVEF and CRP, longer walking distance in 6 min, as well as lower heart rate and blood pressure (both systolic and diastolic) compared to the control group. Similarly, the cardiothoracic proportion and left ventricular internal diameter for the carvedilol and trimetazidine groups was lower than those of the control group, with better clinical effects (p<0.05). In conclusion, the curative effects of the carvedilol and trimetazidine groups of alcoholic myocardiopathy similar. Both are safe agents that may improve the cardiac function and heart expansion of patients. |
| publisher |
D.A. Spandidos |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950288/ |
| _version_ |
1613611589196316672 |