Sprouty2 and ‐4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage

Sprouty2 and ‐4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage

Sprouty (Spry) proteins play a key role as negative feedback inhibitors of the Ras/Raf/MAPK/ERK pathway downstream of various receptor tyrosine kinases. Among the four Sprouty isoforms, Spry2 and Spry4 are expressed in the hippocampus. In this study, possible effects of Spry2 and Spry4 hypomorphism...

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Bibliographic Details
Main Authors: Thongrong, Sitthisak, Hausott, Barbara, Marvaldi, Letizia, Agostinho, Alexandra S., Zangrandi, Luca, Burtscher, Johannes, Fogli, Barbara, Schwarzer, Christoph, Klimaschewski, Lars
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949526/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949526/

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