Challenges in identifying cancer genes by analysis of exome sequencing data

Massively parallel sequencing has permitted an unprecedented examination of the cancer exome, leading to predictions that all genes important to cancer will soon be identified by genetic analysis of tumours. To examine this potential, here we evaluate the ability of state-of-the-art sequence analysi...

Full description

Bibliographic Details
Main Authors: Hofree, Matan, Carter, Hannah, Kreisberg, Jason F., Bandyopadhyay, Sourav, Mischel, Paul S., Friend, Stephen, Ideker, Trey
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947162/