Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection

Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection

The rate at which HIV-1 infected individuals progress to AIDS is highly variable and impacted by T cell immunity. CD8 T cell inhibitory molecules are up-regulated in HIV-1 infection and associate with immune dysfunction. We evaluated participants (n = 122) recruited to the SPARTAC randomised clinica...

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Bibliographic Details
Main Authors: Hoffmann, Matthias, Pantazis, Nikos, Martin, Genevieve E., Hickling, Stephen, Hurst, Jacob, Meyerowitz, Jodi, Willberg, Christian B., Robinson, Nicola, Brown, Helen, Fisher, Martin, Kinloch, Sabine, Babiker, Abdel, Weber, Jonathan, Nwokolo, Nneka, Fox, Julie, Fidler, Sarah, Phillips, Rodney, Frater, John
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945085/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945085/

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