Beta-Catenin Haplo Insufficient Male Mice Do Not Lose Bone in Response to Hindlimb Unloading

As the β-catenin pathway has been shown to be involved in mechanotransduction, we sought to determine if haploinsufficiency would affect skeletal response to unloading. It has previously been shown that deletion of both alleles of β-catenin in bone cells results in a fragile skeleton highly suscepti...

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Bibliographic Details
Main Authors: Maurel, Delphine B., Duan, Peipei, Farr, Joshua, Cheng, An-Lin, Johnson, Mark L., Bonewald, Lynda F.
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943721/