Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis

Various pathophysiologic mechanisms leading to sickness behaviors have been proposed. For example, an inflammatory process in the hypothalamus has been implicated, but the signaling modalities that involve inflammatory mechanisms and neuronal circuit functions are ill-defined. Here, we show that tol...

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Bibliographic Details
Main Authors: Jin, Sungho, Kim, Jae Geun, Park, Jeong Woo, Koch, Marco, Horvath, Tamas L., Lee, Byung Ju
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942617/