In-vivo imaging of dendritic pruning in dentate granule cells

We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment (EE) and constraining dendritic growth by disrupting Wnt signaling led to increased branch addition...

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Bibliographic Details
Main Authors: Gonçalves, J. Tiago, Bloyd, Cooper W., Shtrahman, Matthew, Johnston, Stephen T., Schafer, Simon T., Parylak, Sarah L., Tran, Thanh, Chang, Tina, Gage, Fred H.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941946/