Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02

Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02

Background. HLA strongly influences human immunodeficiency virus type 1 (HIV-1) disease progression. A major contributory mechanism is via the particular HLA-presented HIV-1 epitopes that are recognized by CD8+ T-cells. Different populations vary considerably in the HLA alleles expressed. We investi...

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Bibliographic Details
Main Authors: Leitman, Ellen M., Hurst, Jacob, Mori, Masahiko, Kublin, James, Ndung'u, Thumbi, Walker, Bruce D., Carlson, Jonathan, Gray, Glenda E., Matthews, Philippa C., Frahm, Nicole, Goulder, Philip J.R.
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936641/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936641/

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