Mutations in the Schmallenberg Virus Gc Glycoprotein Facilitate Cellular Protein Synthesis Shutoff and Restore Pathogenicity of NSs Deletion Mutants in Mice

Mutations in the Schmallenberg Virus Gc Glycoprotein Facilitate Cellular Protein Synthesis Shutoff and Restore Pathogenicity of NSs Deletion Mutants in Mice

Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture (termed SBVp32) unexpectedly displayed increased...

Full description

Bibliographic Details
Main Authors: Varela, Mariana, Pinto, Rute Maria, Caporale, Marco, Piras, Ilaria M., Taggart, Aislynn, Seehusen, Frauke, Hahn, Kerstin, Janowicz, Anna, de Souza, William Marciel, Baumgärtner, Wolfgang, Shi, Xiaohong, Palmarini, Massimo
Format: Online
Language:English
Published: American Society for Microbiology 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934738/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934738/

Similar Items