Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients
Some patients with gastroesophageal reflux disease experience persistent reflux symptoms despite proton pump inhibitor therapy. These symptoms reduce their health-related quality of life. Our aims were to evaluate the relationship between proton pump inhibitor efficacy and health-related quality of...
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| Format: | Online |
| Language: | English |
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the Society for Free Radical Research Japan
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933696/ |
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pubmed-4933696 |
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pubmed-49336962016-08-05 Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients Kimura, Yoshihide Kamiya, Takeshi Senoo, Kyouji Tsuchida, Kenji Hirano, Atsuyuki Kojima, Hisayo Yamashita, Hiroaki Yamakawa, Yoshihiro Nishigaki, Nobuhiro Ozeki, Tomonori Endo, Masatsugu Nakanishi, Kazuhisa Sando, Motoki Inagaki, Yusuke Shikano, Michiko Mizoshita, Tsutomu Kubota, Eiji Tanida, Satoshi Kataoka, Hiromi Katsumi, Kohei Joh, Takashi Original Article Some patients with gastroesophageal reflux disease experience persistent reflux symptoms despite proton pump inhibitor therapy. These symptoms reduce their health-related quality of life. Our aims were to evaluate the relationship between proton pump inhibitor efficacy and health-related quality of life and to evaluate predictive factors affecting treatment response in Japanese patients. Using the gastroesophageal reflux disease questionnaire, 145 gastroesophageal reflux disease patients undergoing proton pump inhibitor therapy were evaluated and classified as responders or partial-responders. Their health-related quality of life was then evaluated using the 8-item Short Form Health Survey, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale questionnaires. Sixty-nine patients (47.6%) were partial responders. These patients had significantly lower scores than responders in 5/8 subscales and in the mental health component summary of the 8-item Short Form Health Survey. Partial responders had significantly higher Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale scores, including anxiety and depression scores, than those of responders. Non-erosive reflux disease and double proton pump inhibitor doses were predictive factors of partial responders. Persistent reflux symptoms, despite proton pump inhibitor therapy, caused mental health disorders, sleep disorders, and psychological distress in Japanese gastroesophageal reflux disease patients. the Society for Free Radical Research Japan 2016-07 2016-05-21 /pmc/articles/PMC4933696/ /pubmed/27499583 http://dx.doi.org/10.3164/jcbn.16-9 Text en Copyright © 2016 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kimura, Yoshihide Kamiya, Takeshi Senoo, Kyouji Tsuchida, Kenji Hirano, Atsuyuki Kojima, Hisayo Yamashita, Hiroaki Yamakawa, Yoshihiro Nishigaki, Nobuhiro Ozeki, Tomonori Endo, Masatsugu Nakanishi, Kazuhisa Sando, Motoki Inagaki, Yusuke Shikano, Michiko Mizoshita, Tsutomu Kubota, Eiji Tanida, Satoshi Kataoka, Hiromi Katsumi, Kohei Joh, Takashi |
| spellingShingle |
Kimura, Yoshihide Kamiya, Takeshi Senoo, Kyouji Tsuchida, Kenji Hirano, Atsuyuki Kojima, Hisayo Yamashita, Hiroaki Yamakawa, Yoshihiro Nishigaki, Nobuhiro Ozeki, Tomonori Endo, Masatsugu Nakanishi, Kazuhisa Sando, Motoki Inagaki, Yusuke Shikano, Michiko Mizoshita, Tsutomu Kubota, Eiji Tanida, Satoshi Kataoka, Hiromi Katsumi, Kohei Joh, Takashi Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients |
| author_facet |
Kimura, Yoshihide Kamiya, Takeshi Senoo, Kyouji Tsuchida, Kenji Hirano, Atsuyuki Kojima, Hisayo Yamashita, Hiroaki Yamakawa, Yoshihiro Nishigaki, Nobuhiro Ozeki, Tomonori Endo, Masatsugu Nakanishi, Kazuhisa Sando, Motoki Inagaki, Yusuke Shikano, Michiko Mizoshita, Tsutomu Kubota, Eiji Tanida, Satoshi Kataoka, Hiromi Katsumi, Kohei Joh, Takashi |
| author_sort |
Kimura, Yoshihide |
| title |
Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients |
| title_short |
Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients |
| title_full |
Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients |
| title_fullStr |
Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients |
| title_full_unstemmed |
Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients |
| title_sort |
persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients |
| description |
Some patients with gastroesophageal reflux disease experience persistent reflux symptoms despite proton pump inhibitor therapy. These symptoms reduce their health-related quality of life. Our aims were to evaluate the relationship between proton pump inhibitor efficacy and health-related quality of life and to evaluate predictive factors affecting treatment response in Japanese patients. Using the gastroesophageal reflux disease questionnaire, 145 gastroesophageal reflux disease patients undergoing proton pump inhibitor therapy were evaluated and classified as responders or partial-responders. Their health-related quality of life was then evaluated using the 8-item Short Form Health Survey, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale questionnaires. Sixty-nine patients (47.6%) were partial responders. These patients had significantly lower scores than responders in 5/8 subscales and in the mental health component summary of the 8-item Short Form Health Survey. Partial responders had significantly higher Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale scores, including anxiety and depression scores, than those of responders. Non-erosive reflux disease and double proton pump inhibitor doses were predictive factors of partial responders. Persistent reflux symptoms, despite proton pump inhibitor therapy, caused mental health disorders, sleep disorders, and psychological distress in Japanese gastroesophageal reflux disease patients. |
| publisher |
the Society for Free Radical Research Japan |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933696/ |
| _version_ |
1613604555234213888 |