Platelet‐to‐lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta‐analysis

Platelet‐to‐lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta‐analysis

Inflammation is one of the most important causes leading to colorectal carcinogenesis, and inflammatory biomarkers such as the platelet‐to‐lymphocyte ratio (PLR) might predict survival in colorectal cancer (CRC). However, the prognostic value of PLR in CRC patients remains controversial. The prognos...

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Main Authors: Peng, Hong‐Xin, Lin, Kang, He, Bang‐Shun, Pan, Yu‐Qin, Ying, Hou‐Qun, Hu, Xiu‐Xiu, Xu, Tao, Wang, Shu‐Kui
Format: Online
Language:English
Published: John Wiley and Sons Inc. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932454/
id pubmed-4932454
recordtype oai_dc
spelling pubmed-49324542016-07-08 Platelet‐to‐lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta‐analysis Peng, Hong‐Xin Lin, Kang He, Bang‐Shun Pan, Yu‐Qin Ying, Hou‐Qun Hu, Xiu‐Xiu Xu, Tao Wang, Shu‐Kui Research Articles Inflammation is one of the most important causes leading to colorectal carcinogenesis, and inflammatory biomarkers such as the platelet‐to‐lymphocyte ratio (PLR) might predict survival in colorectal cancer (CRC). However, the prognostic value of PLR in CRC patients remains controversial. The prognostic value of PLR was comprehensively analyzed in 12 articles including 3541 CRC patients (10 for overall survival (OS), seven for disease‐free survival (DFS), three for recurrence‐free survival (RFS), and three for cancer‐specific survival (CSS)) in this study. The overall pooled hazard ratios (HRs) of PLR for OS, DFS, and CSS were significant at 1.29 (95% confidence interval, CI = 1.13–1.47, PH = 0.149), 1.43 (95% CI = 1.03–1.97, PH = 0.025), and 1.26 (95% CI = 1.04–1.52, PH = 0.223), respectively. However, there was no evidence of significance for RFS (HR = 1.29, 95% CI = 0.98–1.70, PH = 0.231) in our study. Stratified analyses indicated elevated PLR was a predictor of poor OS (metastatic patients) and DFS (Caucasian population) and was also significantly associated with OS in univariate analysis (HR = 1.35, 95% CI = 1.14–1.60, PH = 0.532) and those only treated surgically (HR = 1.37, 95% CI = 1.10–1.70, PH = 1.080). However, our findings indicated that elevated PLR is a promising prognostic biomarker for colorectal cancer, especially in metastatic Caucasian CRC patients. John Wiley and Sons Inc. 2016-06-16 /pmc/articles/PMC4932454/ /pubmed/27398314 http://dx.doi.org/10.1002/2211-5463.12083 Text en © 2016 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Peng, Hong‐Xin
Lin, Kang
He, Bang‐Shun
Pan, Yu‐Qin
Ying, Hou‐Qun
Hu, Xiu‐Xiu
Xu, Tao
Wang, Shu‐Kui
spellingShingle Peng, Hong‐Xin
Lin, Kang
He, Bang‐Shun
Pan, Yu‐Qin
Ying, Hou‐Qun
Hu, Xiu‐Xiu
Xu, Tao
Wang, Shu‐Kui
Platelet‐to‐lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta‐analysis
author_facet Peng, Hong‐Xin
Lin, Kang
He, Bang‐Shun
Pan, Yu‐Qin
Ying, Hou‐Qun
Hu, Xiu‐Xiu
Xu, Tao
Wang, Shu‐Kui
author_sort Peng, Hong‐Xin
title Platelet‐to‐lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta‐analysis
title_short Platelet‐to‐lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta‐analysis
title_full Platelet‐to‐lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta‐analysis
title_fullStr Platelet‐to‐lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta‐analysis
title_full_unstemmed Platelet‐to‐lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta‐analysis
title_sort platelet‐to‐lymphocyte ratio could be a promising prognostic biomarker for survival of colorectal cancer: a systematic review and meta‐analysis
description Inflammation is one of the most important causes leading to colorectal carcinogenesis, and inflammatory biomarkers such as the platelet‐to‐lymphocyte ratio (PLR) might predict survival in colorectal cancer (CRC). However, the prognostic value of PLR in CRC patients remains controversial. The prognostic value of PLR was comprehensively analyzed in 12 articles including 3541 CRC patients (10 for overall survival (OS), seven for disease‐free survival (DFS), three for recurrence‐free survival (RFS), and three for cancer‐specific survival (CSS)) in this study. The overall pooled hazard ratios (HRs) of PLR for OS, DFS, and CSS were significant at 1.29 (95% confidence interval, CI = 1.13–1.47, PH = 0.149), 1.43 (95% CI = 1.03–1.97, PH = 0.025), and 1.26 (95% CI = 1.04–1.52, PH = 0.223), respectively. However, there was no evidence of significance for RFS (HR = 1.29, 95% CI = 0.98–1.70, PH = 0.231) in our study. Stratified analyses indicated elevated PLR was a predictor of poor OS (metastatic patients) and DFS (Caucasian population) and was also significantly associated with OS in univariate analysis (HR = 1.35, 95% CI = 1.14–1.60, PH = 0.532) and those only treated surgically (HR = 1.37, 95% CI = 1.10–1.70, PH = 1.080). However, our findings indicated that elevated PLR is a promising prognostic biomarker for colorectal cancer, especially in metastatic Caucasian CRC patients.
publisher John Wiley and Sons Inc.
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932454/
_version_ 1613604124579856384

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