The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

Heat shock protein-90 (Hsp90) is an essential molecular chaperone in eukaryotes involved in maintaining the stability and activity of numerous signalling proteins, also known as clients. Hsp90 ATPase activity is essential for its chaperone function and it is regulated by co-chaperones. Here we show...

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Bibliographic Details
Main Authors: Woodford, Mark R., Dunn, Diana M., Blanden, Adam R., Capriotti, Dante, Loiselle, David, Prodromou, Chrisostomos, Panaretou, Barry, Hughes, Philip F., Smith, Aaron, Ackerman, Wendi, Haystead, Timothy A., Loh, Stewart N., Bourboulia, Dimitra, Schmidt, Laura S., Marston Linehan, W., Bratslavsky, Gennady, Mollapour, Mehdi
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931344/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931344/

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