Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog

Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology and proliferation of Sertoli cells in a cryptorchid testis. In the present study, we investigated the expr...

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Main Authors:	Jung, Hyo Young, Yoo, Dae Young, Jo, Young Kwang, Kim, Geon A, Chung, Jin Young, Choi, Jung Hoon, Jang, Goo, Hwang, In Koo
Format:	Online
Language:	English
Published:	Korean Association for Laboratory Animal Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931037/

id	pubmed-4931037
recordtype	oai_dc
spelling	pubmed-49310372016-07-05 Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog Jung, Hyo Young Yoo, Dae Young Jo, Young Kwang Kim, Geon A Chung, Jin Young Choi, Jung Hoon Jang, Goo Hwang, In Koo Case Report Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology and proliferation of Sertoli cells in a cryptorchid testis. In the present study, we investigated the expression of estrogen and progesterone receptors in the normal and cryptorchid testis of a dog. Elective orchidectomy was performed on the dog's abdominal right testis (undescended, cryptorchid) and scrotal left testis (descended, normal). In the normal testis, estrogen receptor α immunoreactivity was detected in Leydig cells alone, while estrogen receptor α immunoreactivity in the cryptorchid testis was significantly prominent in the Sertoli cells as well. In addition, progesterone receptor immunoreactivity in the control testis was detected in the spermatids, but was not detected in the cryptorchid testis. This result suggests that unilateral cryptorchidism causes increases of estrogen receptor α expression in Sertoli cells. Korean Association for Laboratory Animal Science 2016-06 2016-06-24 /pmc/articles/PMC4931037/ /pubmed/27382382 http://dx.doi.org/10.5625/lar.2016.32.2.128 Text en Copyright © 2016 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Jung, Hyo Young Yoo, Dae Young Jo, Young Kwang Kim, Geon A Chung, Jin Young Choi, Jung Hoon Jang, Goo Hwang, In Koo
spellingShingle	Jung, Hyo Young Yoo, Dae Young Jo, Young Kwang Kim, Geon A Chung, Jin Young Choi, Jung Hoon Jang, Goo Hwang, In Koo Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog
author_facet	Jung, Hyo Young Yoo, Dae Young Jo, Young Kwang Kim, Geon A Chung, Jin Young Choi, Jung Hoon Jang, Goo Hwang, In Koo
author_sort	Jung, Hyo Young
title	Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog
title_short	Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog
title_full	Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog
title_fullStr	Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog
title_full_unstemmed	Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog
title_sort	differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog
description	Descending of the testes is an important process for spermatogenesis and cryptorchidism is one of the most relevant genital defects in dogs. In a previous study, we observed abnormal morphology and proliferation of Sertoli cells in a cryptorchid testis. In the present study, we investigated the expression of estrogen and progesterone receptors in the normal and cryptorchid testis of a dog. Elective orchidectomy was performed on the dog's abdominal right testis (undescended, cryptorchid) and scrotal left testis (descended, normal). In the normal testis, estrogen receptor α immunoreactivity was detected in Leydig cells alone, while estrogen receptor α immunoreactivity in the cryptorchid testis was significantly prominent in the Sertoli cells as well. In addition, progesterone receptor immunoreactivity in the control testis was detected in the spermatids, but was not detected in the cryptorchid testis. This result suggests that unilateral cryptorchidism causes increases of estrogen receptor α expression in Sertoli cells.
publisher	Korean Association for Laboratory Animal Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931037/
_version_	1613603462256263168

Differential expression of estrogen receptor α and progesterone receptor in the normal and cryptorchid testis of a dog

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