Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury
Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of molecular, cellular, and functional alterations that are both part of the wound healing response to form a scar in the infarct region and the consequence of that response. Using the laws of thermodynamics as an analo...
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2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930103/ |
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pubmed-49301032016-07-01 Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury Iyer, Rugmani Padmanabhan Jung, Mira Lindsey, Merry L Article Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of molecular, cellular, and functional alterations that are both part of the wound healing response to form a scar in the infarct region and the consequence of that response. Using the laws of thermodynamics as an analogy, we present here three laws for categorizing the post-MI LV remodeling process. The first law is that the LV will attempt to maintain equilibrium and compensate as a way to maximize function, the second law is that remodeling is progressive and unidirectional, and the third law is that the final goal is (ideally, but not always achievable) a stable, equilibrated scar. This comparison helps to define the boundaries of the system, whether it be the infarct zone, the LV, the heart, or the entire body. This review provides an overview for those not directly in the field and establishes a framework to help prioritize future research directions. 2015-10-30 2015 /pmc/articles/PMC4930103/ /pubmed/27376092 http://dx.doi.org/10.2147/MNM.S74093 Text en This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Iyer, Rugmani Padmanabhan Jung, Mira Lindsey, Merry L |
| spellingShingle |
Iyer, Rugmani Padmanabhan Jung, Mira Lindsey, Merry L Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury |
| author_facet |
Iyer, Rugmani Padmanabhan Jung, Mira Lindsey, Merry L |
| author_sort |
Iyer, Rugmani Padmanabhan |
| title |
Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury |
| title_short |
Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury |
| title_full |
Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury |
| title_fullStr |
Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury |
| title_full_unstemmed |
Using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury |
| title_sort |
using the laws of thermodynamics to understand how matrix metalloproteinases coordinate the myocardial response to injury |
| description |
Following myocardial infarction (MI), the left ventricle (LV) undergoes a series of molecular, cellular, and functional alterations that are both part of the wound healing response to form a scar in the infarct region and the consequence of that response. Using the laws of thermodynamics as an analogy, we present here three laws for categorizing the post-MI LV remodeling process. The first law is that the LV will attempt to maintain equilibrium and compensate as a way to maximize function, the second law is that remodeling is progressive and unidirectional, and the third law is that the final goal is (ideally, but not always achievable) a stable, equilibrated scar. This comparison helps to define the boundaries of the system, whether it be the infarct zone, the LV, the heart, or the entire body. This review provides an overview for those not directly in the field and establishes a framework to help prioritize future research directions. |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930103/ |
| _version_ |
1613603095022927872 |