Identification of ubiquinol cytochrome c reductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma

Identification of ubiquinol cytochrome c reductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma

Ubiquinol cytochrome c reductase hinge (UQCRH) is a novel protein that localizes in the mitochondrial membrane and induces mitochondrial reactive oxygen species (ROS) generation. It had a high expression rate of 87.10% (108/124) in lung adenocarcinoma. Moreover, serum UQCRH level in patients with lu...

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Main Authors: Gao, Feng, Liu, Qicai, Li, Guoping, Dong, Feng, Qiu, Minglian, Lv, Xiaoting, Zhang, Sheng, Guo, Zheng
Format: Online
Language:English
Published: The Royal Society 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929934/
id pubmed-4929934
recordtype oai_dc
spelling pubmed-49299342016-07-15 Identification of ubiquinol cytochrome c reductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma Gao, Feng Liu, Qicai Li, Guoping Dong, Feng Qiu, Minglian Lv, Xiaoting Zhang, Sheng Guo, Zheng Research Ubiquinol cytochrome c reductase hinge (UQCRH) is a novel protein that localizes in the mitochondrial membrane and induces mitochondrial reactive oxygen species (ROS) generation. It had a high expression rate of 87.10% (108/124) in lung adenocarcinoma. Moreover, serum UQCRH level in patients with lung adenocarcinoma was significantly increased compared with that of pneumonia patients (p < 0.0001) and normal control subjects (p < 0.0001). Receiver operating characteristic curve analysis using an optimal cut-off value of 162.65 pg ml−1 revealed sensitivity and specificity for the diagnosis of lung adenocarcinoma of 88.7% and 85.7%, respectively, with an area under the curve of 0.927 (95% CI: 0.892 to 0.962, p < 0.0001). Serum UQCRH discriminates lung adenocarcinoma patients from the population without cancer with considerable sensitivity and specificity, but it does not distinguish between heavy smokers and lung adenocarcinoma patients. Serum UQCRH could be a potential diagnostic biomarker for lung adenocarcinoma. The Royal Society 2016-06-29 /pmc/articles/PMC4929934/ /pubmed/27358292 http://dx.doi.org/10.1098/rsob.150256 Text en © 2016 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Gao, Feng
Liu, Qicai
Li, Guoping
Dong, Feng
Qiu, Minglian
Lv, Xiaoting
Zhang, Sheng
Guo, Zheng
spellingShingle Gao, Feng
Liu, Qicai
Li, Guoping
Dong, Feng
Qiu, Minglian
Lv, Xiaoting
Zhang, Sheng
Guo, Zheng
Identification of ubiquinol cytochrome c reductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma
author_facet Gao, Feng
Liu, Qicai
Li, Guoping
Dong, Feng
Qiu, Minglian
Lv, Xiaoting
Zhang, Sheng
Guo, Zheng
author_sort Gao, Feng
title Identification of ubiquinol cytochrome c reductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma
title_short Identification of ubiquinol cytochrome c reductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma
title_full Identification of ubiquinol cytochrome c reductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma
title_fullStr Identification of ubiquinol cytochrome c reductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma
title_full_unstemmed Identification of ubiquinol cytochrome c reductase hinge (UQCRH) as a potential diagnostic biomarker for lung adenocarcinoma
title_sort identification of ubiquinol cytochrome c reductase hinge (uqcrh) as a potential diagnostic biomarker for lung adenocarcinoma
description Ubiquinol cytochrome c reductase hinge (UQCRH) is a novel protein that localizes in the mitochondrial membrane and induces mitochondrial reactive oxygen species (ROS) generation. It had a high expression rate of 87.10% (108/124) in lung adenocarcinoma. Moreover, serum UQCRH level in patients with lung adenocarcinoma was significantly increased compared with that of pneumonia patients (p < 0.0001) and normal control subjects (p < 0.0001). Receiver operating characteristic curve analysis using an optimal cut-off value of 162.65 pg ml−1 revealed sensitivity and specificity for the diagnosis of lung adenocarcinoma of 88.7% and 85.7%, respectively, with an area under the curve of 0.927 (95% CI: 0.892 to 0.962, p < 0.0001). Serum UQCRH discriminates lung adenocarcinoma patients from the population without cancer with considerable sensitivity and specificity, but it does not distinguish between heavy smokers and lung adenocarcinoma patients. Serum UQCRH could be a potential diagnostic biomarker for lung adenocarcinoma.
publisher The Royal Society
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929934/
_version_ 1613603039382339584

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