Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing compl...

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Bibliographic Details
Main Authors: Stock, Kristin, Estrada, Marta F., Vidic, Suzana, Gjerde, Kjersti, Rudisch, Albin, Santo, Vítor E., Barbier, Michaël, Blom, Sami, Arundkar, Sharath C., Selvam, Irwin, Osswald, Annika, Stein, Yan, Gruenewald, Sylvia, Brito, Catarina, van Weerden, Wytske, Rotter, Varda, Boghaert, Erwin, Oren, Moshe, Sommergruber, Wolfgang, Chong, Yolanda, de Hoogt, Ronald, Graeser, Ralph
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929472/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929472/

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