Functional synergy between the Munc13 C-terminal C1 and C2 domains

Functional synergy between the Munc13 C-terminal C1 and C2 domains

Neurotransmitter release requires SNARE complexes to bring membranes together, NSF-SNAPs to recycle the SNAREs, Munc18-1 and Munc13s to orchestrate SNARE complex assembly, and Synaptotagmin-1 to trigger fast Ca2+-dependent membrane fusion. However, it is unclear whether Munc13s function upstream and...

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Bibliographic Details
Main Authors: Liu, Xiaoxia, Seven, Alpay Burak, Camacho, Marcial, Esser, Victoria, Xu, Junjie, Trimbuch, Thorsten, Quade, Bradley, Su, Lijing, Ma, Cong, Rosenmund, Christian, Rizo, Josep
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927299/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927299/

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