Pilin Vaccination Stimulates Weak Antibody Responses and Provides No Protection in a C57Bl/6 Murine Model of Acute Clostridium difficile Infection

Clostridium difficile is the leading cause of nosocomial infections in the United States, adding billions of dollars per year to health care costs. A vaccine targeted against the bacterium would be extremely beneficial in decreasing the morbidity and mortality caused by C. difficile-associated disea...

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Bibliographic Details
Main Authors: Maldarelli, Grace A, Matz, Hanover, Gao, Si, Chen, Kevin, Hamza, Therwa, Yfantis, Harris G, Feng, Hanping, Donnenberg, Michael S
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927082/