The regulation of hematopoietic stem cell populations
Evidence presented over the last few years indicates that the hematopoietic stem cell (HSC) compartment comprises not just one but a number of different cell populations. Based on HSCs’ proliferation and engraftment potential, it has been suggested that there are two classes of HSC, with long- and s...
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| Format: | Online |
| Language: | English |
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F1000Research
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926728/ |
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pubmed-49267282016-07-11 The regulation of hematopoietic stem cell populations Mayani, Hector Review Evidence presented over the last few years indicates that the hematopoietic stem cell (HSC) compartment comprises not just one but a number of different cell populations. Based on HSCs’ proliferation and engraftment potential, it has been suggested that there are two classes of HSC, with long- and short-term engraftment potential. HSC heterogeneity seems to involve differentiation capacities as well, since it has been shown that some HSC clones are able to give rise to both myeloid and lymphoid progeny, whereas others are lymphoid deficient. It has been recognized that HSC function depends on intrinsic cell regulators, which are modulated by external signals. Among the former, we can include transcription factors and non-coding RNAs as well as epigenetic modifiers. Among the latter, cytokines and extracellular matrix molecules have been implicated. Understanding the elements and mechanisms that regulate HSC populations is of significant relevance both in biological and in clinical terms, and research in this area still has to face several complex and exciting challenges. F1000Research 2016-06-28 /pmc/articles/PMC4926728/ /pubmed/27408695 http://dx.doi.org/10.12688/f1000research.8532.1 Text en Copyright: © 2016 Mayani H http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Mayani, Hector |
| spellingShingle |
Mayani, Hector The regulation of hematopoietic stem cell populations |
| author_facet |
Mayani, Hector |
| author_sort |
Mayani, Hector |
| title |
The regulation of hematopoietic stem cell populations |
| title_short |
The regulation of hematopoietic stem cell populations |
| title_full |
The regulation of hematopoietic stem cell populations |
| title_fullStr |
The regulation of hematopoietic stem cell populations |
| title_full_unstemmed |
The regulation of hematopoietic stem cell populations |
| title_sort |
regulation of hematopoietic stem cell populations |
| description |
Evidence presented over the last few years indicates that the hematopoietic stem cell (HSC) compartment comprises not just one but a number of different cell populations. Based on HSCs’ proliferation and engraftment potential, it has been suggested that there are two classes of HSC, with long- and short-term engraftment potential. HSC heterogeneity seems to involve differentiation capacities as well, since it has been shown that some HSC clones are able to give rise to both myeloid and lymphoid progeny, whereas others are lymphoid deficient. It has been recognized that HSC function depends on intrinsic cell regulators, which are modulated by external signals. Among the former, we can include transcription factors and non-coding RNAs as well as epigenetic modifiers. Among the latter, cytokines and extracellular matrix molecules have been implicated. Understanding the elements and mechanisms that regulate HSC populations is of significant relevance both in biological and in clinical terms, and research in this area still has to face several complex and exciting challenges. |
| publisher |
F1000Research |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926728/ |
| _version_ |
1613601644630507520 |