The end of the road for the tryptophan depletion concept in pregnancy and infection
We hypothesize that: (1) L-tryptophan (Trp) is greatly utilized and not depleted in pregnancy; (2) fetal tolerance is achieved in part through immunosuppressive kynurenine (Kyn) metabolites produced by the flux of plasma free (non-albumin-bound) Trp down the Kyn pathway; (3) the role of indoleamine...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Portland Press Ltd.
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926258/ |