Pharmacological targeting of glucose-6-phosphate dehydrogenase in human erythrocytes by Bay 11–7082, parthenolide and dimethyl fumarate

Pharmacological targeting of glucose-6-phosphate dehydrogenase in human erythrocytes by Bay 11–7082, parthenolide and dimethyl fumarate

In mature erythrocytes, glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) yield NADPH, a crucial cofactor of the enzyme glutathione reductase (GR) converting glutathione disulfide (GSSG) into its reduced state (GSH). GSH is essential for detoxification processes...

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Bibliographic Details
Main Authors: Ghashghaeinia, Mehrdad, Giustarini, Daniela, Koralkova, Pavla, Köberle, Martin, Alzoubi, Kousi, Bissinger, Rosi, Hosseinzadeh, Zohreh, Dreischer, Peter, Bernhardt, Ingolf, Lang, Florian, Toulany, Mahmoud, Wieder, Thomas, Mojzikova, Renata, Rossi, Ranieri, Mrowietz, Ulrich
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926109/

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