Cervical cancer systemic inflammation score: a novel predictor of prognosis
Inflammation contributes to development and progression in a variety of cancers, including cervical cancer. We developed a novel cervical cancer systemic inflammation score (CCSIS) based on the preoperative platelet-to-lymphocyte ratio (PLR) and serum albumin levels. A retrospective analysis of clin...
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| Format: | Online |
| Language: | English |
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Impact Journals LLC
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924782/ |
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pubmed-4924782 |
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pubmed-49247822016-07-13 Cervical cancer systemic inflammation score: a novel predictor of prognosis Zheng, Ru-ru Huang, Min Jin, Chu Wang, Han-chu Yu, Jiang-tao Zeng, Lin-chai Zheng, Fei-yun Lin, Feng Clinical Research Paper Inflammation contributes to development and progression in a variety of cancers, including cervical cancer. We developed a novel cervical cancer systemic inflammation score (CCSIS) based on the preoperative platelet-to-lymphocyte ratio (PLR) and serum albumin levels. A retrospective analysis of clinical data from 795 patients with operable cervical cancer was then conducted to investigate the prognostic value of CCSIS and its association with the patients' clinicopathological features, overall survival (OS), and disease-free survival (DFS). CCSIS was predictive of OS and DFS. High CCSIS was correlated with more advanced FIGO stages, poor tumor differentiation, and the presence of PLN and LVSI. Both albumin levels and the PLR were independent prognostic indicators for operable cervical cancer. The use of the CCSIS could improve risk stratification and traditional clinicopathological analysis in cervical cancer. Impact Journals LLC 2016-02-14 /pmc/articles/PMC4924782/ /pubmed/26885692 http://dx.doi.org/10.18632/oncotarget.7378 Text en Copyright: © 2016 Zheng et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zheng, Ru-ru Huang, Min Jin, Chu Wang, Han-chu Yu, Jiang-tao Zeng, Lin-chai Zheng, Fei-yun Lin, Feng |
| spellingShingle |
Zheng, Ru-ru Huang, Min Jin, Chu Wang, Han-chu Yu, Jiang-tao Zeng, Lin-chai Zheng, Fei-yun Lin, Feng Cervical cancer systemic inflammation score: a novel predictor of prognosis |
| author_facet |
Zheng, Ru-ru Huang, Min Jin, Chu Wang, Han-chu Yu, Jiang-tao Zeng, Lin-chai Zheng, Fei-yun Lin, Feng |
| author_sort |
Zheng, Ru-ru |
| title |
Cervical cancer systemic inflammation score: a novel predictor of prognosis |
| title_short |
Cervical cancer systemic inflammation score: a novel predictor of prognosis |
| title_full |
Cervical cancer systemic inflammation score: a novel predictor of prognosis |
| title_fullStr |
Cervical cancer systemic inflammation score: a novel predictor of prognosis |
| title_full_unstemmed |
Cervical cancer systemic inflammation score: a novel predictor of prognosis |
| title_sort |
cervical cancer systemic inflammation score: a novel predictor of prognosis |
| description |
Inflammation contributes to development and progression in a variety of cancers, including cervical cancer. We developed a novel cervical cancer systemic inflammation score (CCSIS) based on the preoperative platelet-to-lymphocyte ratio (PLR) and serum albumin levels. A retrospective analysis of clinical data from 795 patients with operable cervical cancer was then conducted to investigate the prognostic value of CCSIS and its association with the patients' clinicopathological features, overall survival (OS), and disease-free survival (DFS). CCSIS was predictive of OS and DFS. High CCSIS was correlated with more advanced FIGO stages, poor tumor differentiation, and the presence of PLN and LVSI. Both albumin levels and the PLR were independent prognostic indicators for operable cervical cancer. The use of the CCSIS could improve risk stratification and traditional clinicopathological analysis in cervical cancer. |
| publisher |
Impact Journals LLC |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924782/ |
| _version_ |
1613600941676691456 |