Recreational physical activity and ovarian cancer risk in African American women
The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovarian cancer in an exclusively African American...
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John Wiley and Sons Inc.
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924390/ |
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pubmed-4924390 |
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pubmed-49243902016-06-29 Recreational physical activity and ovarian cancer risk in African American women Abbott, Sarah E. Bandera, Elisa V. Qin, Bo Peres, Lauren C. Moorman, Patricia G. Barnholtz‐Sloan, Jill Schwartz, Ann G. Funkhouser, Ellen Peters, Edward S. Cote, Michele L. Alberg, Anthony J. Terry, Paul Bondy, Melissa Paddock, Lisa E. Crankshaw, Sydnee Wang, Frances Camacho, Fabian Schildkraut, Joellen M. Cancer Prevention The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovarian cancer in an exclusively African American (AA) population. We analyzed data from an ongoing U.S. population‐based, case–control study of AA women, which included 393 women recently diagnosed with invasive epithelial ovarian cancer (IEOC) and 611 controls. A baseline interview assessed RPA frequency, intensity, and duration. Each RPA intensity was assigned a metabolic equivalent of task (MET) value and MET‐min/week were calculated. Unconditional multivariable logistic regression was performed to investigate associations between RPA and IEOC risk. Compared with sedentary women, predominantly mild intensity RPA was significantly inversely associated with IEOC risk for women reporting above median (>297) MET‐min/week (odds ratio [OR] = 0.52; 95% confidence interval [CI]: 0.34, 0.78) and nonsignificantly for <297 MET‐min/week (OR = 0.71; 95% CI: 0.44, 1.12). Predominantly moderate intensity RPA was associated with significantly increased risk for women reporting above median (>540) MET‐min/week (OR = 1.51; 95% CI: 1.03, 2.23). Predominantly strenuous intensity RPA was nonsignificantly associated with lower IEOC risk for women reporting above median (>1800) MET‐min/week (OR = 0.72; 95% CI: 0.33, 1.57). The inverse associations for mild and strenuous intensity RPA were most pronounced in obese women (body mass index >30 kg/m2). The findings that mild and strenuous RPA may reduce the risk of IEOC particularly among obese women are difficult to reconcile with the increased risk observed for moderate RPA. Further research is warranted to determine whether these findings are genuine and, if so, their mechanistic basis. John Wiley and Sons Inc. 2016-02-29 /pmc/articles/PMC4924390/ /pubmed/26923432 http://dx.doi.org/10.1002/cam4.677 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Abbott, Sarah E. Bandera, Elisa V. Qin, Bo Peres, Lauren C. Moorman, Patricia G. Barnholtz‐Sloan, Jill Schwartz, Ann G. Funkhouser, Ellen Peters, Edward S. Cote, Michele L. Alberg, Anthony J. Terry, Paul Bondy, Melissa Paddock, Lisa E. Crankshaw, Sydnee Wang, Frances Camacho, Fabian Schildkraut, Joellen M. |
| spellingShingle |
Abbott, Sarah E. Bandera, Elisa V. Qin, Bo Peres, Lauren C. Moorman, Patricia G. Barnholtz‐Sloan, Jill Schwartz, Ann G. Funkhouser, Ellen Peters, Edward S. Cote, Michele L. Alberg, Anthony J. Terry, Paul Bondy, Melissa Paddock, Lisa E. Crankshaw, Sydnee Wang, Frances Camacho, Fabian Schildkraut, Joellen M. Recreational physical activity and ovarian cancer risk in African American women |
| author_facet |
Abbott, Sarah E. Bandera, Elisa V. Qin, Bo Peres, Lauren C. Moorman, Patricia G. Barnholtz‐Sloan, Jill Schwartz, Ann G. Funkhouser, Ellen Peters, Edward S. Cote, Michele L. Alberg, Anthony J. Terry, Paul Bondy, Melissa Paddock, Lisa E. Crankshaw, Sydnee Wang, Frances Camacho, Fabian Schildkraut, Joellen M. |
| author_sort |
Abbott, Sarah E. |
| title |
Recreational physical activity and ovarian cancer risk in African American women |
| title_short |
Recreational physical activity and ovarian cancer risk in African American women |
| title_full |
Recreational physical activity and ovarian cancer risk in African American women |
| title_fullStr |
Recreational physical activity and ovarian cancer risk in African American women |
| title_full_unstemmed |
Recreational physical activity and ovarian cancer risk in African American women |
| title_sort |
recreational physical activity and ovarian cancer risk in african american women |
| description |
The literature on recreational physical activity (RPA) and ovarian cancer risk is inconclusive and most studies of RPA and ovarian cancer have been conducted in white populations. This study is the first to investigate the association between RPA and ovarian cancer in an exclusively African American (AA) population. We analyzed data from an ongoing U.S. population‐based, case–control study of AA women, which included 393 women recently diagnosed with invasive epithelial ovarian cancer (IEOC) and 611 controls. A baseline interview assessed RPA frequency, intensity, and duration. Each RPA intensity was assigned a metabolic equivalent of task (MET) value and MET‐min/week were calculated. Unconditional multivariable logistic regression was performed to investigate associations between RPA and IEOC risk. Compared with sedentary women, predominantly mild intensity RPA was significantly inversely associated with IEOC risk for women reporting above median (>297) MET‐min/week (odds ratio [OR] = 0.52; 95% confidence interval [CI]: 0.34, 0.78) and nonsignificantly for <297 MET‐min/week (OR = 0.71; 95% CI: 0.44, 1.12). Predominantly moderate intensity RPA was associated with significantly increased risk for women reporting above median (>540) MET‐min/week (OR = 1.51; 95% CI: 1.03, 2.23). Predominantly strenuous intensity RPA was nonsignificantly associated with lower IEOC risk for women reporting above median (>1800) MET‐min/week (OR = 0.72; 95% CI: 0.33, 1.57). The inverse associations for mild and strenuous intensity RPA were most pronounced in obese women (body mass index >30 kg/m2). The findings that mild and strenuous RPA may reduce the risk of IEOC particularly among obese women are difficult to reconcile with the increased risk observed for moderate RPA. Further research is warranted to determine whether these findings are genuine and, if so, their mechanistic basis. |
| publisher |
John Wiley and Sons Inc. |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924390/ |
| _version_ |
1613600778657726464 |